Cheshire Hardcastle, M.Sc.

Graduate Student

CH

Cheshire Hardcastle, M.Sc.

B.S. Psychology, University of Cincinnati, Cincinnati, OH

M.Sc. Neuroimaging for Clinical and Cognitive Neuroscience

E-mail:   chardcastle@ufl.edu
Phone:  TBD

Primary Appointment:

Graduate Student, Woods Lab
Center for Cognitive Aging and Memory
Department of Clinical and Health Psychology
College of Public Health and Health Professions
University of Florida

Professional Interests

Cheshire Hardcastle is a 3rd year doctoral student in the Department of Clinical and Healthy Psychology under the mentorship of Dr. Adam Woods. She completed her B.A. at the University of Cincinnati with a major in Psychology and a minor in Biomedical Humanities, working with Dr. Paula Shear. She then worked for three and a half years with Dr. Edith Sullivan and Dr. Adolf Pfefferbaum in an alcohol and HIV neuroimaging/neuropsychology lab at SRI International and Stanford University administering a battery of neuropsychological assessments as well as a variety of MRI scans.

Cheshire then completed her M.Sc. degree at the University of Manchester in the U.K. in Neuroimaging for Clinical and Cognitive Neuroimaging. Her thesis focused on differences in cerebral perfusion in adults who are positive for amyloid-beta. She is currently researching the affects of cognitive training in healthy older adults and adults with Mild Cognitive Impairment (MCI) on functional brain changes. She is also involved in the ACTIVE Mind project, assessing cognitive training on everyday functioning in individuals with MCI.

Publications & Presentations

Publications

Hardcastle, V.G., and Hardcastle, C. (2015). Addiction, Freedom, and Responsibility. American Journal of Bioethics-Neuroscience, 6(2): 19-21. 

Fama, R., Le Berre, A.P, Hardcastle, C., Sassoon, S. A., Zahr, N. M., Pfefferbaum, A., Sullivan, E.V. (2017) Neurological, nutritional, and alcohol consumption factors underlie cognitive and motor deficits in chronic alcoholism.  Addiction Biology, 24(2): 290-302.

Sassoon, S. A., Le Berre, A.P., Fama, R., Asok, P., Hardcastle, C., Chu, W., Pfefferbaum, A., Sullivan, E. (2017) Effects of childhood trauma and alcoholism history on neuropsychological performance in adults with HIV infection: an initial study. Journal of HIV/AIDS and Infectious Diseases, 3(101): 1-15.

Hardcastle, C., Huang, H., Tanner, J., Parvataneni, H., Ding, M., Price, C. (2018) Acute effects of total knee arthroplasty with general anesthesia on functional brain networks in patients with mild cognitive impairment. [Abstract] Anesthesia & Analgesia, 126, 330.

Tanner, J., Amin, M., Hardcastle, C., Paryataneni, H., Mareci, T., Price, C. (2019) Better brain and cognition prior to surgery is associated with elevated post-operative brain extracellular free-water in older adults. Frontiers in Aging Neuroscience, 11: 1-9.  

Hardcastle, C., Huang, H., Crowley, S., Tanner, J., Paryataneni, H., Ding, M., Price, C. (2019) Mild Cognitive Impairment and Decline in Resting State Functional Connectivity after Total Knee Arthroplasty with General Anesthesia. Journal of Alzheimer’s Disease, 69, 1003-1018.

Publications Under Review

Fama, R., Muller-Oehring, E., Hendershott, T., Hardcastle, C., Goodcase, R., Martin, T., Prabhakar, V., Bronte-Stewart, H., Poston, K., Schulte, T. (2019) Cognitive and motor functioning in older adults with HIV infection: A comparison with Parkinson’s disease (in review).

Publications in Preparation

Dion, D., Arias, F., Hardcastle, C., Amini, S., David, R., Tighe, P., Price, C. (In progress) Cognitive Associates of the digital clock drawing test in older adults: total clock time and pre-first hand latency.

Book Chapters

Hardcastle, C., Taylor, B., Price, Catherine. (2019). Global Deterioration Scale. In Encyclopedia of Gerontology and Population Aging. (in press with Springer).

Taylor, B., Hardcastle, C., Marsiske, M. (2019). Central Nervous System. In Encyclopedia of Gerontology and Population Aging. (in press with Springer).

Published Abstracts and Presentations

Hardcastle, C., Marlatt, E., Bennet, M., and Sarkoc, J. (2012). Judging Affordance by Hefting in Preschoolers.  Undergraduate Research Expo, University of Cincinnati. 

Hardcastle, C., Hardcastle, V.G. (2014). Brain scans in the Courtroom: Cautions, Challenges, and Concerns. International Neuroethics Society Annual Meeting. Washington, D.C.

Fama, R., Sassoon, S.A., Hardcastle, C., Rohlfing, T., Sullivan, E., Pfefferbaum, A. (2015). Temporo-parietal contribution to visual episodic memory performance in HIV infection. International Neuropsychology Society Annual Meeting. Denver, CO. 

Collins, A. M., Hardcastle, C., Zahr, N. M., Sullivan, E.V., Pfefferbaum, A. (2015). In vivo imaging evidence for variable CNS responses to repeated binge ethanol treatment. Annual SRI Biosciences Poster Day. Menlo Park, CA

Hardcastle, C., Hardcastle, V. (2015). Addiction, maladaptive behavior, and responsibility. International Neuroethics Society Annual Meeting, Chicago, Illinois.

Hardcastle, C., and Hardcastle, V.G. (2015) Brain plasticity, neuroimaging, and the courtroom. American Society for Bioethics and Humanities Annual Meeting, Houston, TX.

Peterson, E., Zahr, N. M., Serventi, M., Hardcastle, C., Sullivan, E.V., Pfefferbaum, A. (2016). Intra voxel incoherent motion in the brain: a repeatability and aging study. Abstract no. 1094. Proceedings of the International Society of Magnetic Resonance in Medicine Annual Conference, Singapore.

Muller-Oehring, E.M., Poston, K.M., Bronte-Stewart, H., Hardcastle, C., Martin, T., Pfefferbaum, A., Sullivan, E.V., Schulte, T. (2016) Aging with HIV infection – neurofunctional response to cognitive interference and motor demands: a comparison with Parkinson’s Disease. Society for Neuroscience, San Diego, California.  

Sassoon, S.A., Le Berre, A.P., Fama, R., Asok, P., Hardcastle, C., Chu, W., Bonilla, A., Pfefferbaum, A., Sullivan, E.V. (2016) Relation between early childhood trauma and cognitive and motor performance in HIV-infected adults with and without alcoholism. Research Society on Alcoholism, New Orleans, LA. 

Fama, R., Hardcastle, C., Sassoon, S., Zahr, N., Pfefferbaum, A., Sullivan, E. (2016) Neurological and nutritional biomarkers of cognitive impairment in alcoholics. International Neuropsychological Society, New Orleans, LA.

Hardcastle, C., Hendershott, T.R., Fama R., Muller-Oehring, E.M., Sullivan, E.V., Pfeffermaum, A., Poston, K.L., Bronte-Stewart, H.M., Schulte, T. (2017) Cognitive and motor functioning in older adults with HIV: A comparison with Parkinson’s disease. International Neuropsychological Society, New Orleans, LA.

Tanner, J., Hardcastle, C., Amin, M., Paryataneni, H., Mareci, T., Price, C. (2018) Non-demented older adult brains show widespread white matter extracellular free-water 48 hours after total knee arthroplasty with general anesthesia. International Anesthesia Research Society, Chicago, IL.

Dion, D., Arias, F., Hardcastle, C., Amini, S., David, R., Tighe, P., Price, C. (2018) Cognitive Associates of the digital clock drawing test in older adults: total clock time and pre-first hand latency. International Anesthesia Research Society, Chicago, IL.

Hardcastle, C.,  Huang, H., Tanner, J., Paryataneni, H., Ding, M., Price, C. (Submitted as late-breaking abstract, 2018) MCI versus non-MCI brain changes in resting state networks 48 hours after total knee arthroplasty with general anesthesia. International Anesthesia Research Society, Chicago, IL.

Carter, S., Hinz, R., Hardcastle, C.,  Amadi, C., Parkes, L., Pendleton, N.,  Herholz, K. (2018) [18 F]Flutemetamol PET imaging reveals interaction between relative cerebral blood flow, fibrillar amyloid pathology and memory in non-demented elderly. Functional Neuroreceptor Mapping of the Living Brain, London, England.

Hardcastle, C., Amin, M., Crowley, S., Vanderbilt, D., Wiggins, M., Dion, C., Hizel, L., Tanner, J., Vaillancourt, D., Mareci, T., Price, C. (2019) Hippocampal Free Water and Episodic Memory in Mild Cognitive Impairment. International Neuropsychological Society, New York, New York.

Hardcastle, C. Huang, H., Tanner, J., Parvataneni, H., Ding, M., Price. C.  (2019) The Left Angular Gyrus and Dorsal Anterior Cingulate Cortex: Key Regions for Pre-Post Operative Functional Resting State Decline? International Anesthesia Research Society, Montreal, Quebec.