Cognitive Training and Mild Cognitive Impairment
The portion of the US population 65 years and older is rapidly increasing, with the population of 65+ older adults expected to double by 2050. In turn, the number of people in the population diagnosed with mild cognitive impairment (MCI) and Alzheimer’s disease is expected to potentially triple by this time. There is a pressing need for effective interventions to slow or remediate decline in cognitive function and functional abilities in older adults with MCI. This two-year National Institute on Aging funded U01 (Edwards, PI) will establish the infrastructure necessary to implement a large multisite clinical trial investigating one of the most promising non-invasive approaches for improving MCI outcomes: cognitive training. Using an adaptive clinical trial design, sites at the University of Florida (Woods), University of South Florida (Edwards), and University of California San Francisco (Kramer) will test a series of different cognitive training methods on MCI functional outcome. The study will build the multisite infrastructure necessary for a subsequent large definitive trial and collect important pilot data for determining the optimal cognitive training regime for further study. The study will include multimodal neuroimaging data for investigating mechanistic effects of cognitive training in MCI, as well as predictors of individual treatment response. This study represents an important step forward in the field of cognitive training and in the fight against age-related cognitive decline and dementia.
National Institute on Aging U01AG062368